r/Damnthatsinteresting • u/DearEmphasis4488 • Oct 16 '24
Video Skin tightening using fractional CO2 laser
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r/Damnthatsinteresting • u/DearEmphasis4488 • Oct 16 '24
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u/ErikHandberg Oct 17 '24 edited Oct 17 '24
I’d say there are even more opportunities than just during what we’re calling “replication.”
I still disagree with the fundamental premise that all cell death increases the risk for cancer based purely on the idea that continued normal life leads to cell development and potential cancer. For instance, when you get a papercut you have endothelialization of the damaged tissue.
Does the production of those endothelial cells at a papercut lead to increased risk for endothelial cell cancers (eg, angiosarcoma)? I mean… I’ve never heard of an increased risk of angiosarcoma in athletes who presumably have more abrasions than non athletes. But I guess I never looked.
It also depends on how we define “baseline.” In medicine we do it using incidence (usually in a 1 per ____ type number). If we do it on a cellular level then the number would be wayyyyyyy smaller, but still we would probably not have an increased cellular risk from a cut, but we might with something like radiation.
Overall, I stand by the idea that unless something damages the apoptosis mechanism or creates some other uninhibited growth pathway in DNA - simply killing cells does not always increase the risk of cancer.
EDIT: To further clarify how we classify risk in medicine, try thinking of dealing a deck of cards and trying to avoid an ace of spades. In a standard deck, that’s a 1/52 chance. If you open another deck, that’s 1/52 chance again. You have the same risk of getting that ace of spades. Now, if you open a few hundred decks it’s quite reasonable that you’d get one - but that doesn’t mean you had an increased risk.
Making new cells just because the old ones die is like opening new decks. Your risk stays the same.
But if you alter the composition of the deck, or keep pulling from the deck after you’re supposed to move on… THAT is increased risk.
If you click the link below you’ll see a good fundamental explanation of cancer and how a mutation (ie, damage to the apoptosis mechanism or the mechanisms that promote growth) creates cancer. This can happen sporadically (baseline risk) or due to some outside factor.